Intracellular NLR (Nucleotide‐binding domain and Leucine‐rich Repeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided (...) novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Music Education in an Age of Virtuality and Post-Truth by Paul WoodfordPanagiotis A. KanellopoulosPaul Woodford, Music Education in an Age of Virtuality and Post-Truth (New York, Routledge, 2018)This book is provocative. And challenging. It is written with passion, aiming to induce controversy. And with good reason. For we live in times when populism professes an illusionary sense of community, invoking a seemingly 'anti-systemic' but highly hypocritical, racist, and (...) sexist discourse;1 in times where "bullshitting"2 has advanced to the highest governmental levels in many countries; in times where "authoritarian neoliberal statism"3 becomes the new status quo, inducing a scandalous increase of economic inequalities, forcing large populations to live precarious lives; in times where privatization of educational services in the context of market-oriented practices impose restrictive and ultimately unjust politics of accountability and performativity;4 in times where instrumentalization of educational ends has taken the lead, assisted by a systematic co-option and misappropriation of notions such as excellence and creativity;5 in times, finally, where spaces that allow for "the sharing (out) of the incalculable,"6 forging unknown potentialities in education, life, and thought, are being destroyed. In such times, Paul Woodford has stepped in, reclaiming his right to speak uncompromisingly.Hannah Arendt has written that "[w]hen men [sic] are deprived of the public space--which is constituted by acting together and then fills of its own accord [End Page 108] with the events and stories that develop into history--they retreat into their freedom of thought."7 Woodford refuses to retreat. He writes as a public intellectual of the highest order, committed to upset and not please those in power. A great service that his latest book performs is that it speaks daringly, stirring a debate that helps us all to do away with fear. For as Bertrand Russell has aptly said quite a long time ago, "[I]f thought is to become the possession of many, not the privilege of the few, we must have done with fear. It is fear that holds men [sic] back."8Resisting the "melancholy of inner exile,"9 but not immune to possible accusations of left melancholy, understood as "a refusal to come to terms with the particular character of the present,"10 the author wrote a book that provokes music educators to actively think beyond their sealed and safe world of convictions that is based on ideology-free conceptions of music teaching. Estelle Jorgensen has long ago brought to our attention the urgency of this task: "in an era in which the mindset and political reality have changed dramatically, … there is an urgent need to revisit the political character of music education and the ways in which it needs to address the cultural issues of our day."11Along this pathway, Woodford's book encourages music educators to live and teach as public intellectuals, forging "a democratic purpose for music education"12 that acts against the "anachronistic and formalist conception of music that reduces music education to supply-side economics as children are conceived as either future professional musicians or consumers and not as citizens to be prepared in schools to participate intelligently in the political life of society."13 Woodford articulates a vision of music education "as preparation for adulthood and democratic and global citizenship."14 He strongly advocates an approach that balances performance and creativity-based experiences with a socio-historical study of the social, ideological, and cultural workings of different musics in a wide variety of contexts. He encourages music educators to teach "how music's structural properties and qualities contribute to the shaping of people's perceptions and understandings of themselves and their world,"15 "asking the who, what, when, where, how, to, with, or for whom, and, most importantly of all, why of music."16 He envisions a music classroom that exercises social criticism "directly and self-consciously"17 both through "learning how to make music"18 and through thinking about music. He sees this approach as a tool for raising students' consciousness. Woodford's ultimate vision of music education is one that casts it as a means for cultivating "a justice-oriented" approach... (shrink)

In A Philosophy for Communism: Rethinking Althusser Panagiotis Sotiris attempts a reading of the work of the French philosopher centered upon his deeply political conception of philosophy. Althusser's endeavour is presented as a quest for a new practice of philosophy that would enable a new practice of politics for communism, in opposition to idealism and teleology. The central point is that in his trajectory from the crucial interventions of the 1960s to the texts on aleatory materialism, Althusser remained a (...) communist in philosophy. This is based upon a reading of the tensions and dynamics running through Althusser's work and his dialogue with other thinkers. Particular attention is paid to crucial texts by Althusser that remained unpublished until relatively recently. (shrink)

Platonism and Christian Thought in Late Antiquity examines the various ways in which Christian intellectuals engaged with Platonism both as a pagan competitor and as a source of philosophical material useful to the Christian faith. The chapters are united in their goal to explore transformations that took place in the reception and interaction process between Platonism and Christianity in this period. -/- The contributions in this volume explore the reception of Platonic material in Christian thought, showing that the transmission of (...) cultural content is always mediated, and ought to be studied as a transformative process by way of selection and interpretation. Some chapters also deal with various aspects of the wider discussion on how Platonic, and Hellenic, philosophy and early Christian thought related to each other, examining the differences and common ground between these traditions. -/- Platonism and Christian Thought in Late Antiquity offers an insightful and broad ranging study on the subject, which will be of interest to students of both philosophy and theology in the Late Antique period, as well as anyone working on the reception and history of Platonic thought, and the development of Christian thought. (shrink)

Different why-questions emerge under different contexts and require different information in order to be addressed. Hence a relevance relation can hardly be invariant across contexts. However, what is indeed common under any possible context is that all explananda require scientific information in order to be explained. So no scientific information is in principle explanatorily irrelevant, it only becomes so under certain contexts. In view of this, scientific thought experiments can offer explanations, should we analyze their representational strategies. Their representations involve (...) empirical as well as hypothetical statements. I call this the “representational mingling” which bears scientific information that can explain events. Buchanan’s thought experiment from constitutional economics is examined to show how mingled representations explain. (shrink)

"Plato's Statesman reconsiders many questions familiar to readers of the Republic: questions in political theory - such as the qualifications for the leadership of a state and the best from of constitution (politeia) - as well as questions of philosophical methodology and epistemology. Instead of the theory of Forms that is the centrepiece of the epistemology of the Republic, the emphasis here is on the dialectical practice of collection and division (diairesis), in whose service the interlocutors also deploy the ancillary (...) methods of myth and of models (paradeigmata). Plato here introduces the doctrine of due measure (to metrion) and a conception of statecraft (politikē) as an architectonic expertise that governs subordinate disciplines such as rhetoric and the military - doctrines later developed by Aristotle. Readers will find a sustained defence of the importance of expertise (technē or epistēmē) in the conduct of affairs of state, a robust (although not unqualified) defence of the rule of law, and an unsparing but nuanced critique of democratic government. The chapters in this volume provide a comprehensive and detailed philosophical engagement with the entirety of Plato's wide-ranging dialogue, with successive chapters devoted to the sections of the dialogue as it unfolds, and an introduction that places the dialogue in the context of Plato's philosophy as a whole. While not a commentary in the traditional sense, the volume engages with Plato's Statesman in its entirety" -- Publisher's description. (shrink)

The ontic conception of explanation is predicated on the proposition that “explanation is a relation between real objects in the world” and hence, according to this approach, scientific explanation cannot take place absent such a premise. Despite the fact that critics have emphasized several drawbacks of the ontic conception, as for example its inability to address the so-called “abstract explanations”, the debate is not settled and the ontic view can claim to capture cases of explanation that are non-abstract, such as (...) causal relations between events. However, by eliminating the distinction between abstract and non-abstract explanations, it follows that ontic and epistemic proposals can no longer contend to capture different cases of explanation and either all are captured by the ontic view or all are captured by the epistemic view. On closer inspection, it turns out that the ontic view deals with events that fall outside the scientists’ scope of observation and that it does not accommodate common instances of explanation such as explanations from false propositions and hence it cannot establish itself as the dominant philosophical stance with respect to explanation. On the contrary, the epistemic conception does account for almost all episodes of explanation and can be described as a relation between representations, whereby the explanans transmit information to the explanandum and that this information can come, dependent on context, in the form of any of the available theories of explanation (law-like, unificatory, causal and non-causal). The range of application of the ontic view thus is severely restricted to trivial cases of explanation that come through direct observation of the events involved in an explanation and explanation is to be mostly conceived epistemically. (shrink)

This monograph evaluates public policy responses to the Covid-19 pandemic through a public choice lens. The book compares two prominent, albeit mutually exclusive, theories in social sciences—public interest theory and public choice theory—and explores how their predictions perform within the framework of the Covid-19 pandemic. The chapters present different pandemic policies alongside empirical data in order to draw conclusions about their efficacy, and, in turn, draw conclusions about the veracity of each theory. By the end of the volume, the reader (...) will be able to draw their own conclusions about whether the pandemic policy responses served the public interest, as public interest theory suggests, or the personal interests of the politicians who implemented them, as public choice theory holds. (shrink)

Until recently, cardiotoxicity in the setting of a malignant disease was attributed solely to the detrimental effects of chemo‐ and/or radio‐therapy to the heart. On this account, the focus was on the evaluation of well‐established cardiac biomarkers for the early detection of myocardial damage. Currently, this view has been revised. Cardiotoxicity is not restricted to a single organ but instead affects the endothelium as a whole. Indeed, it has come into light that not only cancer therapy but also malignant cells (...) per se can impair the cardiovascular system, through a paracrine and endocrine mode of action. Even more intriguingly, a clear interplay between molecular pathways involved in cancer and cardiovascular disease has become prevalent, suggesting a common nominator that governs the pathophysiology of these two entities. Taken together, our strategy in the quest of novel biomarkers in the emerging field of cardio‐oncology should be critically reshaped. (shrink)

The model of ownership psychology as a cognitive adaptation proposes that people flexibly navigate cognitive systems of cooperation and competition, thus enabling them to justify unethical behavior. We discuss how this model captures previous accounts of unethical behavior and propose that a disengagement heuristic can help us understand recent findings in the interconnection between scarcity psychology and unethical behavior.

White liberals like to claim that they live in a post-racial society. Furthermore, they believe that most people do not sympathize with the far-right. However, it is not racism fueling right-wing extremism in North America and Western Europe but the dominant ideology, liberalism. Consequently, Slavoj Žižek argues that racism is a problem concerning “objective violence,” which he further breaks down into “symbolic violence” and “systemic violence.” These primarily target minority groups. Thus, “objective violence” best explains the West’s problematic views of (...) Muslims and Islam since it supports what Edward Said refers to as “Orientalism” and reproduces racist depictions of racialized communities. These are incredibly harmful since the West still perceives the Orient and its residents as violent, strange, and backward. These Orientalist attitudes ultimately lead to discrimination against Muslims and Arabs. Furthermore, this ideology naturalizes and legitimizes capitalist social relations while concealing racialization processes. (shrink)

The ontic conception of explanation is predicated on the proposition that “explanation is a relation between real objects in the world” and hence, according to this approach, scientific explanation cannot take place absent such a premise. Despite the fact that critics have emphasized several drawbacks of the ontic conception, as for example its inability to address the so-called “abstract explanations”, the debate is not settled and the ontic view can claim to capture cases of explanation that are non-abstract, such as (...) causal relations between events. However, by eliminating the distinction between abstract and non-abstract explanations, it follows that ontic and epistemic proposals can no longer contend to capture different cases of explanation and either all are captured by the ontic view or all are captured by the epistemic view. On closer inspection, it turns out that the ontic view deals with events that fall outside the scientists’ scope of observation and that it does not accommodate common instances of explanation such as explanations from false propositions and hence it cannot establish itself as the dominant philosophical stance with respect to explanation. On the contrary, the epistemic conception does account for almost all episodes of explanation and can be described as a relation between representations, whereby the explanans transmit information to the explanandum and that this information can come, dependent on context, in the form of any of the available theories of explanation (law-like, unificatory, causal and non-causal). The range of application of the ontic view thus is severely restricted to trivial cases of explanation that come through direct observation of the events involved in an explanation and explanation is to be mostly conceived epistemically. (shrink)

Immersive virtual reality (VR) emerges as a promising research and clinical tool. However, several studies suggest that VR induced adverse symptoms and effects (VRISE) may undermine the health and safety standards, and the reliability of the scientific results. In the current literature review, the technical reasons for the adverse symptomatology are investigated to provide suggestions and technological knowledge for the implementation of VR head-mounted display (HMD) systems in cognitive neuroscience. The technological systematic literature indicated features pertinent to display, sound, motion (...) tracking, navigation, ergonomic interactions, user experience, and computer’s hardware that should be considered by the researchers. Subsequently, a meta-analysis of 44 neuroscientific or neuropsychological studies involving VR HMD systems was performed. The meta-analysis of the VR studies demonstrated that the new generation HMDs induced significantly fewer dropouts and VRISE. Importantly, the commercial versions of the new generation HMDs with ergonomic interactions had zero incidents of adverse symptomatology and dropouts. Solely, HMDs equivalent to or greater than the commercial versions of contemporary HMDs accompanied with ergonomic interactions are suitable for implementation in cognitive neuroscience. In conclusion, researchers’ technological competency, along with meticulous methods and reports pertinent to software, hardware, and VRISE, are paramount to ensure the health and safety standards and the reliability of neuroscientific results. (shrink)

Exploring both the intrapersonal (moral) and interpersonal (ethical) nature of death and dying in the context of their development (philosophical), Dying in a Transhumanist and Posthuman Society shows how death and dying have been and will continue to be governed in any given society. Drawing on transhumanism and discourses about posthumanity, life prolongation and digital life, the book analyses death, dying and grief via the governance of dying. It states that the bio-medical dimensions of our understanding of death and dying (...) have predominated not only the discourses about death in society and the care of the dying, but their policy and practice as well. It seeks to provoke thinking beyond the benefits of technology and within the confinements of the world transhumanists describe. This book is written for all who have an interest in thanatology (i.e. death studies) but will be useful specifically to those investigating the experiences of dying and grieving in contemporary societies, wherein technology, biology and medicine continuously advance. Thus, the manuscript will be of interest to researchers in a broad range of areas including health and social care, social policy, anthropology, sociology, philosophy, cultural studies, and, of course, thanatology. (shrink)

This article is divided into two parts: in the first we explore the academic debate conducted at an international level about insider trading (IT). In particular, we exame IT on three grounds: economic, ethical and legal. In each section we present the arguments in favour of and against IT and then we give our personal opinion. In the second part we present the situation in the Athens Stock Exchange. We examine its past record on the issue of IT and recent (...) developments, and comment on the implications for the future. (shrink)

We present various results regarding the decidability of certain sets of sentences by Simple Type Theory. First, we introduce the notion of decreasing sentence, and prove that the set of decreasing sentences is undecidable by Simple Type Theory with infinitely many zero-type elements ; a result that follows directly from the fact that every sentence is equivalent to a decreasing sentence. We then establish two different positive decidability results for a weak subtheory of math formula. Namely, the decidability of math (...) formula and math formula. Finally, we present some consequences for the set of existential-universal sentences. All the above results have direct implications for Quine's theory of “New Foundations” and its weak subtheory math formula. (shrink)

The paper examines more broadly the intellectual formation, early carreer and research activity of Franz Dölger with the aim to elucidate, on the one hand, the shift that took place in Byzantine Studies in Munich during the Thirties of the previous century from a philological to a historical direction. On the other hand, the paper offers a detailed analysis of Dölger’s concept of Byzantine literature and its history, the development of this concept and its immediate impact on Byzantine Philology as (...) a separate field within Byzantine Studies. Pivotal in understanding Dölger’s concept are his connection with and use of the Nazi regime and its ideology, as well as a latent but visible antagonism to Karl Krumbacher. The paper includes an analysis of hitherto unknown publications of Dölger from the Nazi era and a number of unpublished documents pertaining to the Athos Expedition of July 1941 and its aftermath. (shrink)

Name der Zeitschrift: Byzantinische Zeitschrift Jahrgang: 108 Heft: 1 Seiten: 1-52.

Neuroplasticity, the capacity of the brain to induce changes in response to environmental stimuli, entails a continuous rearrangement of the neural network through a complex interaction between genetics and environment. Within this process, the plastic brain uses its internal representations to predict future conditions and proactively proceed to actions. It can be said that plasticity demands a rethinking of the concept of determinism as the process of coming-to-be is directly related to modifications produced by experience. Pure determinism and complete randomness (...) are the two ends of a spectrum of positions relevant to the debate of the existence of free will. However, none conceptually supports free decision-making. How brain activity and the conscious experience of volition are related to one another has been a matter of significant research, with a plethora of findings indicating that early brain signals precede the self-reported time of the decision to act. The meaning of these findings, however, has been debated at both a theoretical and empirical level and the controversy is still ongoing. Consciousness is intertwined with free will along the dimension of time as it would otherwise be purposeless, taking place right at the next moment. Electrical activity of the brain is a measure of neurophysiological function and contributes to the understanding of processes that underlie high-order cognitive functions. A multidisciplinary approach in the study of free will could be designed in a way that philosophical concepts are connected to neural correlates by psychologically functionalizing them in terms of cognitive abilities. Such abilities are at the margins of conscious and nonconscious sensory information and are closely linked to brain processes of executive functions like attentional control and working memory. (shrink)

Appearing in English for the first time, Schelling’s 1842 lectures develop the idea that many philosophical concepts are born of religious-mythological notions.

COVID-19 is not only a health emergency but also a strategic challenge for any politics of resistance, struggle and transformation. Understanding the social and political dynamics associated with morbidity and mortality and the many ‘ecologies of disease’ associated with the pandemic is necessary if we want to think beyond the limits of the lockdown strategy. It is here that the possibility of a democratic biopolitics emerges as part of a broader strategy for communism.

Events regarding individuals’ preferences that do not always follow from standard measures such as “value of statistical life” or “quality-adjusted life years” as well as events that occur in some market-related settings which distort the information conveyed by price mechanisms, suggest that a notable chunk of what Hayek called “local knowledge” remains inaccessible by scientific tools and that only the individuals who interact in these local frameworks can have access to it. This casts serious doubt on the epistemic possibility of (...) economic calculation for if events in the local world do not observe the economic models, it is hard to see how central planners can have knowledge on them. Refined modeling strategies and cutting-edge Artificial Intelligence systems do not manage to overcome this hurdle. They may provide huge datasets in a data model, but since not all events represented in the data model are embeddable in known economic models, the knowledge problem is not evaded. Even if a theory ever manages to capture all possible events as they appear in the data model then we are left with a relationship between models (the theoretical model and the data model) with no direct access to the local world and thus the problem of accessibility of local knowledge remains unresolved. (shrink)